Probing the Intracellular Redox Status of Tumors with Magnetic Resonance Imaging and Redox-Sensitive Contrast Agents
نویسندگان
چکیده
منابع مشابه
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents.
Nitroxide radicals are paramagnetic contrast agents, used in magnetic resonance imaging (MRI), that also exert antioxidant effects. Participating in cellular redox reactions, they lose their ability to provide contrast as a function of time after administration. In this study, the rate of contrast loss was correlated to the reducing power of the tissue or the "redox status." The preferential re...
متن کاملHigh-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
PURPOSE There is considerable research directed toward the identification and development of functional contrast agents for medical imaging that superimpose tissue biochemical/molecular information with anatomical structures. Nitroxide radicals were identified as in vivo radioprotectors. Being paramagnetic, they can provide image contrast in magnetic resonance imaging (MRI) and electron paramag...
متن کاملmagnetic resonance imaging contrast agents: a review of literature
magnetic resonance imaging (mri) contrast agents most commonly agents used in diagnosing different diseases. several agents have been ever introduced with different peculiar characteristics. they vary in potency, adverse reaction and other specification, so it is important to select the proper agent in different situations. we conducted a systematic literature search in medline/pubmed, web of s...
متن کاملFactors Associated with Requesting Magnetic Resonance Imaging during the Management of Glomus Tumors
Background: The characteristic clinical presentation of glomus tumors and the low negative predictive value of themagnetic resonance imaging (MRI) raise the question whether MRI improves their management. Therefore, this studyaimed to investigate whether MRI improved the management of glomus tumors.Methods: In total, 87 patients with a histologically confirmed glomus tumor wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-0879